Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
Identifieur interne : 000634 ( Main/Exploration ); précédent : 000633; suivant : 000635Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
Auteurs : Jaegyun Lim [Corée du Sud] ; Seunghyun Jeon [Corée du Sud] ; Hyun-Young Shin [Corée du Sud] ; Moon Jung Kim [Corée du Sud] ; Yu Min Seong [Corée du Sud] ; Wang Jun Lee [Corée du Sud] ; Kang-Won Choe [Corée du Sud] ; Yu Min Kang [Corée du Sud] ; Baeckseung Lee [Corée du Sud] ; Sang-Joon Park [Corée du Sud]Source :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2020.
Abstract
Since mid-December of 2019, coronavirus disease 2019 (COVID-19) has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
Url:
DOI: 10.3346/jkms.2020.35.e79
PubMed: 32056407
PubMed Central: 7025910
Affiliations:
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last="Lim">Jaegyun Lim</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jeon, Seunghyun" sort="Jeon, Seunghyun" uniqKey="Jeon S" first="Seunghyun" last="Jeon">Seunghyun Jeon</name><affiliation wicri:level="1"><nlm:aff id="A2">New Horizon Cancer Institute, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shin, Hyun Young" sort="Shin, Hyun Young" uniqKey="Shin H" first="Hyun-Young" last="Shin">Hyun-Young Shin</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Moon Jung" sort="Kim, Moon Jung" uniqKey="Kim M" first="Moon Jung" last="Kim">Moon Jung Kim</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seong, Yu Min" sort="Seong, Yu Min" uniqKey="Seong Y" first="Yu Min" last="Seong">Yu Min Seong</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Internal Medicine, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country 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Kang</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Infectious Diseases, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Baeckseung" sort="Lee, Baeckseung" uniqKey="Lee B" first="Baeckseung" last="Lee">Baeckseung Lee</name><affiliation wicri:level="1"><nlm:aff id="A7">CancerROP, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Park, Sang Joon" sort="Park, Sang Joon" uniqKey="Park S" first="Sang-Joon" last="Park">Sang-Joon Park</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Korean Medical Science</title><idno type="ISSN">1011-8934</idno><idno type="eISSN">1598-6357</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Since mid-December of 2019, coronavirus disease 2019 (COVID-19) has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kim, Jy" uniqKey="Kim J">JY Kim</name></author><author><name sortKey="Choe, Pg" uniqKey="Choe P">PG Choe</name></author><author><name sortKey="Oh, Y" uniqKey="Oh Y">Y Oh</name></author><author><name sortKey="Oh, Kj" uniqKey="Oh K">KJ Oh</name></author><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name></author><author><name sortKey="Park, Sj" uniqKey="Park S">SJ Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamer, M" uniqKey="Hamer M">M Hamer</name></author><author><name sortKey="Kivimaki, M" uniqKey="Kivimaki M">M Kivimaki</name></author><author><name sortKey="Stamatakis, E" uniqKey="Stamatakis E">E Stamatakis</name></author><author><name sortKey="Batty, Gd" uniqKey="Batty G">GD Batty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Guan, X" uniqKey="Guan X">X Guan</name></author><author><name sortKey="Wu, P" uniqKey="Wu P">P Wu</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author><author><name sortKey="Tong, Y" uniqKey="Tong Y">Y Tong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rothe, C" uniqKey="Rothe C">C Rothe</name></author><author><name sortKey="Schunk, M" uniqKey="Schunk M">M Schunk</name></author><author><name sortKey="Sothmann, P" uniqKey="Sothmann P">P Sothmann</name></author><author><name sortKey="Bretzel, G" uniqKey="Bretzel G">G Bretzel</name></author><author><name sortKey="Froeschl, G" uniqKey="Froeschl G">G Froeschl</name></author><author><name sortKey="Wallrauch, C" uniqKey="Wallrauch C">C Wallrauch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, D" uniqKey="Chang D">D Chang</name></author><author><name sortKey="Lin, M" uniqKey="Lin M">M Lin</name></author><author><name sortKey="Wei, L" uniqKey="Wei L">L Wei</name></author><author><name sortKey="Xie, L" uniqKey="Xie L">L Xie</name></author><author><name sortKey="Zhu, G" uniqKey="Zhu G">G Zhu</name></author><author><name sortKey="Dela Cruz, Cs" uniqKey="Dela Cruz C">CS Dela Cruz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Lim, Jaegyun" sort="Lim, Jaegyun" uniqKey="Lim J" first="Jaegyun" last="Lim">Jaegyun Lim</name></noRegion><name sortKey="Choe, Kang Won" sort="Choe, Kang Won" uniqKey="Choe K" first="Kang-Won" last="Choe">Kang-Won Choe</name><name sortKey="Jeon, Seunghyun" sort="Jeon, Seunghyun" uniqKey="Jeon S" first="Seunghyun" last="Jeon">Seunghyun Jeon</name><name sortKey="Kang, Yu Min" sort="Kang, Yu Min" uniqKey="Kang Y" first="Yu Min" last="Kang">Yu Min Kang</name><name sortKey="Kim, Moon Jung" sort="Kim, Moon Jung" uniqKey="Kim M" first="Moon Jung" last="Kim">Moon Jung Kim</name><name sortKey="Lee, Baeckseung" sort="Lee, Baeckseung" uniqKey="Lee B" first="Baeckseung" last="Lee">Baeckseung Lee</name><name sortKey="Lee, Wang Jun" sort="Lee, Wang Jun" uniqKey="Lee W" first="Wang Jun" last="Lee">Wang Jun Lee</name><name sortKey="Park, Sang Joon" sort="Park, Sang Joon" uniqKey="Park S" first="Sang-Joon" last="Park">Sang-Joon Park</name><name sortKey="Seong, Yu Min" sort="Seong, Yu Min" uniqKey="Seong Y" first="Yu Min" last="Seong">Yu Min Seong</name><name sortKey="Shin, Hyun Young" sort="Shin, Hyun Young" uniqKey="Shin H" first="Hyun-Young" last="Shin">Hyun-Young Shin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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